prae doc (PhD position) Cellular Basis of Diseases (BB-A2809)
Gefunden in: Neuvoo AT
This PhD project is part of the PhD Program Cellular Basis of Diseases (CBD) () at the Medical University of Innsbruck, Austria. The PhD program offers 15 fully funded PhD positions. The interdisciplinary PhD projects address the molecular control of metabolism & inflammation and connect basic life science and computational biology with medicine. The Medical University of Innsbruck is one of the largest facilities that connects basic - and clinical research in Austria. The range of studies covers human medicine and molecular medicine and offers access to state-of-the-art research and core facilities. In addition, the location in the ‚Heart of the Alps‘ offers an international flair and a wide range of outdoors activities with a high quality standard of living.
It is our overall goal to provide control of metabolism and inflammation on the molecular, intra- and intercellular level in health and disease.
Project 10: Genetic Control Of The Immuno-metabolic Interface In Fatty Liver And Hepatocellular Carcinoma
The Question: Fatty liver disease is a spectrum disorder affecting up to 50% of the general population. Its manifestations range from asymptomatic non-progressive hepatic triglyceride accumulation to cirrhosis and hepatocellular carcinoma. Lipid droplet accumulation is the hallmark of fatty liver disease and is caused by a massive alteration of the lipid environment, cellular metabolism, and the molecular membrane architecture in all subcellular compartments. The underlying molecular changes of this dramatic morphologic change, the mediators of inflammation, fibrosis, and carcinogenesis are so far only superficially understood.
The Goal is to mechanistically link the changes in lipidome with the occurrence of known and novel genetic risk factors for f atty liver disease by combining tandem mass spectrometric lipidomics (REF) and patient centered and population genetics utilizing state-of-the-art bioinformatics approaches.
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work Medical University of Innsbruck